Pre~Seed^EQ ~ Veterinarian Overview

Clinically proven in independent studies to not harm sperm from the time of collection, through 48 hours of cold storage.

Based on the same patented, isotonic formula as the only lubricant indicated by FDA for use during human fertility procedures.

With the plant polysaccharide arabinogalactan, for antioxidant support.

Pre~Seed EQ is uniquely formulated to provide lubrication, while optimizing sperm function: 

	The ONLY lubricant to not decrease stallion sperm motility during either fresh or cold storage in independent studies.
	Does not interfere with the ability of sperm to fertilize eggs, or support subsequent embryo development, even after exposure to high concentrations of 50% (v/v).
	Developed by a DVM, PhD, Theriogenologist with over 15 years of federal funding in sperm physiology.
	Does not cause mucous membrane irritation, as does KY Jelly®, making it a better choice for sensitive mares and stallions, or for any medical procedure requiring mucosal lubrication.
	An excellent sheath cleaner, with a little going a long way, and no rinsing required.
	Isotonic, non-irritating formula makes it excellent for wound cleaning and dressing.

How Do Other Lubricants Harm Sperm?

 

	Zero percent fertilization or embryo development after exposure to 10% Priority Care in a bovine in vitro fertilization model.
	A motile sperm decline of over 30% within 3 hrs of contact to "non-spermicidal" veterinary lubricants in a fresh storage setting, as well as over the 48 hrs of routine cold storage.

Although the loss of sperm motility after contact with lubricants is widely reported, it is just now being understood that this abnormal sperm motility is, more importantly, associated with decrease in the sperm’s ability to fertilize an egg and support normal embryo development.

Also Meyers (2007), has reported that hyperosmotic conditions cause cytoskeleton reorganization in sperm, leading to sublethal motility and morphology defects associated with damaged fertilization potential. 

pH - The window for optimal stallion sperm function is narrower than for other species, being between 7.2 and 7.8,  with a rapid decline in motility seen for pH levels above 8.0. Most lubricants have pH values below this optimal level. Sperm motility losses occur with acidic pH exposure.  Conversely, pH levels above 8.0 can cause sperm to undergo acrosome loss and death. In order to protect sperm from pH changes, lubricant pH must be stable during contact with air during handling.  This requires a buffer, such as the phosphate buffers used in Pre~Seed EQ.  Products that utilize sodium bicarbonate as a buffer (e.g. MiniLube) may cause sperm damage through pH increases to alkaline levels (outside of a CO2 incubator).   This may be why sperm motility declines have been reported with 10%  concentrations of Minilube® (Samper, 2007).